Prepare artichokes for steaming: Snap off tough outer leaves. Cut off the top 1/3 of artichoke. Snip remaining sharp or spiky tips using kitchen shears. Trim stem of artichoke.
Add water, garlic cloves, lemon wedges and a couple pinches of salt to your Instant Pot.
Place artichokes in a single layer on the steamer basket, stem side up. Close lid and set the vent to "sealing".
Select "Manual" mode, leave the setting on High Pressure, and adjust the time based on the size of your artichokes: 5 minutes for small, 10 minutes for medium, 15 minutes for large. When the time is up, turn the vent to "venting" for a quick pressure release.