Preheat oven to 350°F. Grease a 9-inch x 13-inch pan.
Crumb Topping:
In a medium bowl, stir together 1 cup brown sugar, 1/2 cup granulated sugar, 1/2 teaspoon salt and 1 1/2 Tablespoons cinnamon. Add the melted 1 cup butter and stir until well combined. Using a fork, mix in the 2 1/2 cups flour until well combined and crumbs form.
Cake:
Mix together the 2 1/2 cups flour, 3/4 teaspoon baking powder, 1 teaspoon baking soda and 1/2 teaspoon salt in a medium size bowl until well combined, set aside.
Using an electric mixer, cream the 1 1/2 sticks butter until smooth. Slowly add in 1 1/2 cups sugar and beat until fluffy. Incorporate 2 eggs and scrape down the sides of the bowl. Add 1 1/4 cups greek yogurt and 1 teaspoon vanilla and beat until just combined. Slowly add in the dry ingredients and beat until fully combined.
Pour the batter into the prepared pan and top with large chunks of the crumb mixture.
Bake for 45-50 minutes, until a fork inserted into the middle comes out clean.
Notes
Store any leftovers tightly wrapped on your counter for up to three days.